The Missouri section of the Great River Road is historic in many ways. From the birthplace of Mark Twain, to the start of the Lewis and Clark expedition, the Missouri Great River Road has some of the most famous historic sites on the entire River Road.
Please be aware that the ‘Official’ Great River Road does not go to the Gateway Arch or the rest of the St. Louis riverfront attractions. If you want to see these sights, you will need to take a detour away from the Official Great River Road.
The Missouri section of the Great River Road is divided into 2 parts; Keokuk, Iowa to Herculaneum and Herculaneum to Blytheville, AR.
Note: We have created 2 sets of routes for each state. 1 is for riding North to South and the other is for riding South to North. Each route is notated either N to S (for North to South) or S to N (for South to North).
Location: Eastern Missouri
Approximate Mileage: 410 miles
Estimated Riding Time: 8.75 hours
Surface: Paved
Attractions:
- Hannibal - Molly Brown Birthplace & Museum, Mark Twain Boyhood Home, Lover’s Leap
- Blytheville - Historic Hwy 61 Arch