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The Missouri section of the Great River Road is historic in many ways.  From the birthplace of Mark Twain, to the start of the Lewis and Clark expedition, the Missouri Great River Road has some of the most famous historic sites on the entire River Road.


Please be aware that the ‘Official’ Great River Road does not go to the Gateway Arch or the rest of the St. Louis riverfront attractions.  If you want to see these sights, you will need to take a detour away from the Official Great River Road.


The Missouri section of the Great River Road is divided into 2 parts; Keokuk, Iowa to Herculaneum and Herculaneum to Blytheville, AR.


Note:  We have created 2 sets of routes for each state.  1 is for riding North to South and the other is for riding South to North.  Each route is notated either N to S (for North to South) or S to N (for South to North).


Location:  Eastern Missouri

Approximate Mileage:  410 miles

Estimated Riding Time:  8.75 hours 

Surface:  Paved




  • Hannibal - Molly Brown Birthplace & Museum, Mark Twain Boyhood Home, Lover’s Leap
  • Blytheville - Historic Hwy 61 Arch

Great River Road - Missouri

  • If you are riding with a group, we ask that every person using our route for navigation purchase their own copy.


    In order to encourage this, we are happy to offer a discount for group purchases. Please contact us after purchasing 1 item at full price, and we will set up a coupon code that will give everyone in your group 50% off of the same item.

  • Our digital routes are designed to operate in most GPS devices.  In addition to GPSs, our routes should work with several smartphone apps.  They will NOT work on Google Maps or Apple Maps.


    If you plan on using a smartphone app, we recommend the REVER app.  REVER will work with both Android and iOS and in addition to navigation it has many other great features.


    For best results in REVER, download the route to your computer first, then import into your smartphone.  Turn by turn may not work, so we recommend that you utilize the "Follow the Line" option. 


    You can get 20% off your first year’s subscription to REVER by following THIS LINK.

    AND using this coupon code at checkout:  Driftlessforless.


    By using this link and coupon code a portion of your subscription fee will go to support Driftless Roads USA.

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